06/07
2023
Seminar
- Title题目 Untangling the Complexity of Circuit-Host Interactions to Design Robust and Predictable Gene Circuits
- Speaker报告人 田晓军 (美国亚利桑那州立大学)
- Date日期 2023年6月7日 10:00
- Venue地点 Zoom 会议：https://us02web.zoom.us/j/83429847853?pwd=SUErV1lud0dMN284RFNXUzB3Z09sQT09 会议号：834 2984 7853 密码：577349
Abstract摘要
Failure of modularity remains a significant challenge for assembling synthetic gene circuits with tested modules as they often do not function as expected. Hidden circuit-host interactions, such as growth feedback and resource competition, could significantly impair intended circuit function but are often overlooked. In this presentation, I will discuss our latest research to use mathematical modeling to quantitatively understand and predict the impact of network topology, host physiology, and resource competition on the functional behaviors of gene circuits. First, we will discuss how the interference of synthetic gene circuit function by growth feedback depends on circuit network topology and nutrient level. Second, we will demonstrate how resource competition redirected desired successive cell fate transitions following a ‘winner-takes-all’ rule. Third, we will highlight our control strategies against resource competition, including a division of labor using microbial consortia, and negatively competitive regulation (NCR) controllers. Lastly, we will discuss the effects of resource competition on circuit noise behavior. Overall, our work will help us in the understanding and control of circuit-host interactions toward engineering robust synthetic gene circuits.
报告人简介：
田晓军, 美国亚利桑那州立大学担任助理教授，博士生导师，美国国家科学基金会青年科学基金奖获得者，美国国立卫生研究院MIRA基金奖获得者。2007年于西北大学获得学士学位, 2012年于南京大学物理学院获得博士学位，2012年至2014年在美国弗吉尼亚理工大学从事博士后研究工，2014年至2017年在美国匹兹堡大学大学从事博士后研究工作。 多年来从事定量系统生物学和合成生物学研究，已在Nature Chemical Biololgy、Nature Communications, PNAS、Cancer Research、ACS Synthetic Biology、Science Signaling等国际权威期刊上发表高水平SCI论文30余篇。
邀请人：
王维康 副研究员
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