11/02
2023
Seminar
- Title题目 The Iron Game: Unveiling the Forces Driving Biodiversity
- Speaker报告人 李志远 (北京大学定量生物学中心)
- Date日期 2023年11月2日 10:00
- Venue地点 南楼6620 https://us06web.zoom.us/j/83686731666?pwd=qC7RPGrIzpec8zNtbUcwzUY5vIwZ03.1 会议号: 836 8673 1666 密码: 605734
Abstract摘要
李志远，北京大学，前沿交叉学科研究院定量生物学中心，北大-清华联合生命科学中心，研究员
Competition for bioavailable iron is a key driver in shaping microbial communities. Microbes commonly synthesize and secrete natural products known as siderophores to chelate iron in their local environment. Subsequently, these iron-siderophore complexes are selectively absorbed by receptors on cellular membranes. Through an analysis of sequence coevolution between siderophore receptors and synthetases, we have reconstructed the most comprehensive siderophore-mediated iron interaction network to date.
Our investigation has revealed the widespread occurrence of "cheating" behavior among microbes, where they exploit siderophores without producing them. Utilizing resource-partitioning and eco-evolutionary models, we have characterized the critical roles of cheating in promoting dynamic coexistence within microbial communities. We also highlight two opposing forces that contribute to siderophore diversity: the inclination towards cheating and the drive to avoid being cheated.
In this talk, we will delve into the intricate game of iron and its role in shaping biodiversity, shedding light on the complex interactions that govern microbial ecosystems.
报告人简介：
李志远，北京大学，前沿交叉学科研究院定量生物学中心，北大-清华联合生命科学中心，研究员
邀请人：
王维康 副研究员
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